Chromatin Signaling and Diseases
Edited by: Olivier Binda, Principle Investigator at Newcastle Cancer Center at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, England, Martin Ernesto Fernandez-ZapicoAssociate Professor of Medicine and Co-Director, Epigenetics and Chromatin Dynamics Research Group, Mayo Clinic, Rochester, MN, USA
Description
Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling.
After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's, and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will need to stay familiar with genetic advances that translate to clinical practice, such as chromatin signaling.
Although sequencing of the human genome was completed over a decade ago and its structure investigated for nearly half a century, molecular mechanisms that regulate gene expression remain largely misunderstood. An emerging concept called chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is reviewed in Chromatin Signaling and Diseases. Finally, the impact of gene expression defects associated with malfunctioning chromatin signaling is also explored.
Key Features
- Explains molecular mechanisms that regulate gene expression, which governs everything from embryonic development, growth, and human pathologies associated with aging
- Educates clinicians and researchers about chromatin signaling, a molecular mechanism that is changing our understanding of human pathology
- Explores the addition and removal of chemical modifications on histones, the proteins that specifically recognize these, and the impact of gene expression defects associated with malfunctioning chromatin signaling
- Helps researchers learn about the quickly expanding field of chromatin signaling
Readership
Geneticists, clinical researchers, life science researchers, MD/clinicians who want to learn about epigenetics and chromatin, cell biologists, molecular biologists and biochemists
Table of Contents:
- Section I: Histone Mark Writers
- Histone acetyltransferases, key writers of the epigenetic language
Xiang-Jiao Yang - Impacts of histone lysine methylation on chromatin
Sylvain Lanouette, John Haddad, Pamela Zhang and Jean-François Couture - The Role of Histone Mark Writers in Chromatin Signaling: Protein Arginine Methyltransferases
Nasim Haghandish and Jocelyn Côté - Histone Kinases and Phosphatases
Nikolaus A. Watson, Jonathan M.G. Higgins - The Bromodomain as Acetyl-Lysine Readers
Steven G. Smith, and Ming-Ming Zhou - Chromo domain proteins
Joel C. Eissenberg - The role of PHD fingers in chromatin signaling: mechanisms and functional consequences of the recognition of histone and non-histone targets
Emma A. Morrison and Catherine A. Musselman - Tudor domains as methyl-lysine and methyl-arginine readers
Maria Victoria Botuyan and Georges Mer - Histone deacetylase, the erasers of the code
María Julia Lamberti, Emanuel Renzo Vera, Natalia Rumie Vittar Belén, Güenter Schneider - Lysine Demethylases: Structure, Function and Disfunction
María Alejandra García, Raquel Fueyo, and Marian A. Martínez-Balbás - Variation, modification and reorganization of broken chromatin
Timothy C. Humphrey, Jessica A. Downs, and Anna L. Chambers - Cross-talk between histone modifications integrates various signaling inputs to fine tune transcriptional output
Sankari Nagarajan and Steven A. Johnsen - Signaling and Chromatin Networks in Cancer Biology
Elisabeth Hessmann, Raul Urrutia, and Alexander Koenig - Crosstalk between DNA methylation and Chromatin Structure
María Roqué and Laura Vargas-Roig - Epigenetic regulation of endoplasmic reticulum stress
Kim Barroso and Eric Chevet - Chromatin Signaling in Aging and Cellular Senescense
Florence Couteau and Frédérick A. Mallette - Chromatin Dynamics and Epigenetics of Stem Cells and Stem-Like Cancer Cells
Alexandre Gaspar-Maia and Ana Sevilla - Altered Chromatin Signaling in Cancer
Andrew Liss - Impact of Chromatin Changes in Pathogenesis of Infectious Disease: A Pathogen View
Andrea Ropolo and Maria Carolina Touz - Chromatin Remodeling and Epigenetic Reprogramming In Chronic Disease and Cancer in the Liver and Pancreas
Maite G. Fernandez - Barrena and Christopher L. Pin - Pharmacological and Therapeutic Targeting of Epigenetic Regulators
Raul Urrutia and Gwen A. Lomberk - Use of Chromatin Changes as Biomarkers
Ryan A. Hlady and Keith D. Robertson - Regulation of Host Chromatin by Bacterial Metabolites
Sridhar Mani
Section II: Histone Mark Readers
Section III: Histone Mark Erasers
Section IV: Chromatin Signaling
Section V: Chromatin Dynamics in Normal and Disease Conditions
Available now from Store.Elsevier.com!
https://www.elsevier.com/books/chromatin-signaling-and-diseases/binda/978-0-12-802389-1