Elsevier · Tollefsbol, T: Translational Epigenetics Series · Genome Stability

Genome Stability

Edited by: Igor Kovalchuk, Principle Investigator, Planet Biotechnology Laboratory, University of Lethbridge, Lethbridge, AB, Canada, Olga KovalchukPrinciple Investigator, Human Epigenetics Laboratory, University of Lethbridge, Lethbridge, AB, Canada

Description

Genome Stability: From Virus to Human Application covers the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, with the latter including major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, as well as changes in genome stability in response to aging.

Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species.

This book teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments. The book also covers how epigenetic factors contribute to genome stability and how species pass the memory of the encounters to the progeny, thus influencing the genome of the progeny in an indirect manner.

Key Features

  • Includes a collection of chapters on genome stability research from various kingdoms, including topics such as epigenetics and transgenerational effects
  • Provides the first comprehensive coverage of the differences in the mechanisms utilized by different organisms to maintain genomic stability
  • Contains applications of genome instability and its effect on human diseases
  • Explains how various species maintain the fine balance in genome stability and genome diversification in response to their environments

Readership

Geneticists, clinical researchers, life science researchers, molecular/cellular biologists, advanced undergraduate and graduate students in genetics, molecular biology, cell biology, and biophysics

Table of Contents

    Introduction
  1. Genome stability – an evolutionary perspective
    Igor Kovalchuk

    2. I. Genome Instability of Viruses

  2. Genetic Instability of RNA Viruses
    John N. Barr and Rachel Fearns
  3. Genome instability in DNA viruses
    Rafael Sanjuán, Marianoel Pereira-Gómez, Jennifer Risso

    4. II. Genome instability in Bacteria and Archaea

  4. Genome instability in bacteria and archaea: Strategies for maintaining genome stability
    Jan-Erik Messling and Ashley B. Williams
  5. Genome instability in bacteria: causes and consequences
    Ashley B. Williams
  6. CRISPR - bacteria immune system
    Andrey Golubov

    7. III. Genome Stability of Unicellular Eukaryotes

  7. Programmed DNA rearrangement in ciliates
    Franziska Jönsson
  8. Homologous Recombination and Non-homologous End-joining repair in yeast
    Rebecca E. Jones and Timothy C. Humphrey

    9. IV. Genome stability in multicellular eukaryotes

  9. Meiotic and Mitotic Recombination: First in Flies
    Julie Korda Holsclaw, Talia Hatkevich and  Jeff Sekelsky
  10. Genome stability in Drosophila – mismatch repair and genome stability
    Tomoe Negishi
  11. Genome stability in Caenorhabditis elegans
    Matthias Rieckher, Amanda Franqueira C. Lopes and Björn Schumacher
  12. Genetic Engineering of Plants using Zn-fingers, TALENs and CRISPRs
    Andriy Bilichak and Francois Eudes
  13. Plant Genome Stability – General Mechanisms
    Andriy Bilichak

    14. V. Genome stability in mammals

  14. Cell cycle control and DNA damage signalling in mammals
    Valenti Gomez and Alexander Hergovich
  15. The role of p53/p21/p16 in DNA damage signalling and DNA repair
    Yavuz Kulaberoglu, Ramazan Gundogdu, and Alexander Hergovich
  16. Roles of RAD18 in DNA Replication and Post-Replication Repair (PRR)
    Cyrus Vaziri, Satoshi Tateishi, Liz Mutter-Rottmayer and Yanzhe Gao
  17. Base Excision Repair and Nucleotide Excision Repair
    Tadahide Izumi and Isabel Mellon
  18. DNA Mismatch Repair in Mammals
    Mingzhang Yang and Peggy Hsieh
  19. Repair of double strand breaks by non-homologous end joining; its components and their function
    Patryk Moskwa
  20. Double-Strand Break Repair: Homologous Recombination in Mammalian Cells
    Camille Gelot, Tangui Le-Guen, Sandrine Ragu and Bernard S. Lopez
  21. Telomere maintenance and genome stability
    Wilnelly Hernandez-Sanchez, Mengyuan Xu and Derek J. Taylor
  22. The relationship between checkpoint adaptation and mitotic catastrophe in genomic changes in cancer cells
    Lucy H. Swift and Roy M. Golsteyn
  23. Chromatin, nuclear organization and genome stability in mammals
    Lora Boteva, Nick Gilbert
  24. Role of DNA methylation in genome stability
    Dan Zhou and Keith D. Robertson
  25. Non-coding RNAs in genome integrity
    Igor Kovalchuk

    26. VI. Human diseases associated with genome instability

  26. Human diseases associated with genome instability
    Bruno César Feltes, Joice de Faria Poloni, Kendi Nishino Miyamoto and Diego Bonatto
  27. Cancer and genomic instability
    Wei Wei, Yabin Cheng and Bo Wang
  28. Chromatin Modifications in DNA Repair and Cancer
    Margaret Renaud-Young, Karl Riabowol and Jennifer Cobb
  29. Genomic Instability and Aging – Causes and Consequences
    Corinne Sidler
  30. Nucleolar contributions to DNA damage response and genomic (in)stability in the nervous system
    Michal Hetman

    31. VII. Effect of environment on genome stability

  31. Diet and nutrition
    Lynnette R. Ferguson
  32. Chemical Carcinogens and Their Effect on Genome and Epigenome Stability,
    Olga Kovalchuk
  33. Environmental sources of ionizing radiation and their health consequences
    Aaron A. Goodarzi, Alexander Anikin, Dustin D. Pearson

    34. VIII. Bystander and transgenerational effects – epigenetic perspective

  34. Sins of Fathers Through a Scientific Lens: Transgenerational Effects
    M. Merrifield, Olga Kovalchuk
  35. Genomic Instability and the Spectrum of Response to Low Radiation Doses
    Carmel Mothersill and Colin Seymour
  36. Transgenerational genome instability in plants
    Igor Kovalchuk
  37. Methods for the detection of DNA damage
    Denis V. Firsanov, Ljudmila V. Solovjeva, Vyacheslav M. Mikhailov, Maria P. Svetlova
  38. Conserved and divergent features of DNA repair. Future perspectives in genome instability research
    Igor Kovalchuk

Available now at Store.Elsevier.com!
https://www.elsevier.com/books/genome-stability/kovalchuk/978-0-12-803309-8