Elsevier · Tollefsbol, T: Translational Epigenetics Series · Personalized Epigenetics

Personalized Epigenetics

Edited by: Trygve O. Tollefsbol, University of Alabama at Birmingham
Director of the Cell Senescence Culture Facility, Birmingham, AL, USA

Description
Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy.

The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics.

Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.

Key Features

  • Discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures
  • Details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the consequent diagnostic, prognostic and therapeutic potential of the field
  • Reviews the impact of the environment on epigenetic variations among individuals and the roles of pharmacology and drug development
  • Devotes several chapters to the advances made in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management
    • Readership
    • Advanced undergraduate students, graduate students, health care professionals, university researchers, and pharmaceutical and biotechnology companies interested in drug development. This book could also serve as a core textbook for advanced university or professional school courses with a focus on genetic and/or human diseases

Table of Contents

Section I: Overview

  1. Epigenetics of Personalized Medicine

    2. Section II: Epigenetic Variations Among Individuals

  2. Inter-individual Variability of DNA Methylation
  3. Differences in Histone Modifications Between Individuals
  4. Individual Noncoding RNA Variations: Their Role in Shaping and Maintaining the Epigenetic Landscape
  5. Personalized Epigenetics: Analysis and Interpretation of DNA Methylation Variation

    6. Section III: Bioinformatics of Personalized Epigenetics

  6. Computational Methods in Epigenetics

    7. Section IV: Diagnostic and Prognostic Epigenetic Approaches to Personalized Medicine

  7. Epigenetic Biomarkers in Personalized Medicine
  8. Epigenetic ‘Fingerprint’
  9. Epigenetics of Personalized Toxicology

    10. Section V: Environmental Personalized Epigenetics

  10. Environmental Contaminants and their Impacts on the Epigenome
  11. Nutriepigenomics: Personalized Nutrition Meets Epigenetics

    12. Section VI. Pharmacology and Drug Development of Personalized Epigenetics

  12. Personalized Pharmacoepigenomics
  13. Personalized Medicine and Epigenetic Drug Development

    14. Section VII: Personalized Epigenetics of Disorders and Disease Management

  14. Epigenetics and Personalized Pain Management
  15. Understanding Inter-individual Epigenetic Variations in Obesity and its Management
  16. Epigenetic Modification of miRNAs in Cancer
  17. Managing Autoimmune Disorders Through Personalized Epigenetic Approaches
  18. Cardiovascular Diseases and Personalized Epigenetics

    19. Section VIII: Challenges and Future Directions

  19. Future Challenges and Prospects for Personalized Epigenetics

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