Welcome to the website for Alpern, Caplan, Moe: Seldin and Giebisch’s The Kidney, 5th Edition. Physiology & Pathophysiology.
A classic nephrology reference for over 25 years, Seldin & Giebisch's The Kidney, is the acknowledged authority on renal physiology and pathophysiology. The Fifth Edition places increased emphasis on normal physiologic regulation and its disruption by disease with detailed attention to the specific mechanisms underlying pathologic changes. By developing the most fundamental advances in renal physiology, not simply as isolated achievements, but as key ingredients to the understanding of physiologic regulation, the fifth edition constitutes a unique synthesis of normal regulation and its disruption by disease.
One of the appealing features of nephrology is the ability to utilize our understanding of normal physiology to elucidate principles of pathophysiology and secondarily develop rational approaches to the diagnosis, treatment and prevention of disease. Thus the clinician addressing a patient with a fluid and electrolyte disorder need not memorize a list of possible causes or algorithms, but can logically deduce a solution through a thorough understanding of kidney function. As science continues to evolve, our understanding of the pathophysiologic basis of disease can now be applied to a much broader set of ailments. Each new edition of The Kidney, therefore, continues to broaden its scope of so as to place greater emphasis on mechanisms of disease.