Neuromodulation
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Table of Contents*
*Contents are tentative and subject to change prior to publication. List denotes lead author only.

Prologue
Joseph Pancrazio

SECTION I: INTRODUCTION
Introduction
Elliot S. Krames

Chapter 1: What Is Neuromodulation?
Elliot S. Krames, Ali R. Rezai, P. Hunter Peckham, and Farag Aboelsaad

Chapter 2: Neuromodulation: A Historical Perspective
Philip L. Gildenberg

Chapter 3: Neuromodulation Technologies: Whom Do We Serve?
Allen R. Dyer and Mary Pat Aardrup

Chapter 4: Challenges in Moving Toward Product Development
Paul Meadows

Chapter 5: The Birth of an Industry
James Cavuoto

Chapter 6: Beginnings of the Societies
Ross Davis, Philip L. Gildenberg, Giancarlo Barolat, Elliot S. Krames, Dejan Popovic, and Paul Meadows

Chapter 7: Clinical Study Design
Daniel B. Carr and Anthony Eidelman

Chapter 8: Psychological Issues and Evaluation for Patients Undergoing Implantable Technology
Daniel M. Doleys

Chapter 9: Deep Brain Stimulation: Ethical Issues in Clinical Practice and Neurosurgical Research
Joseph J. Fins

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SECTION II: FUNDAMENTALS OF NEUROMODULATION

Introduction
Narendra Bhadra, J. Thomas Mortimer, and P. Hunter Peckham

Chapter 10: Anatomy of the Nervous System
Joshua M. Rosenow

Chapter 11: Fundamentals of Electrical Stimulation
J. Thomas Mortimer and Narendra Bhadra

Chapter 12: Neuromodulation and Neuronal Plasticity
Alon Y. Mogilner

Chapter 13: Gene-Based Neuromodulation
Thais Federici, Jonathan Riley, and Nicholas Boulis

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SECTION II A: Mechanisms

Introduction

Chapter 14: Principles of Electric Field Generation for Stimulation of the Central Nervous System
Warren M. Grill

Chapter 15: Mechanisms of Action of Deep Brain Stimulation: A Review
Kendall Lee, Charles Blaha, and Jonathan M. Bledsoe

Chapter 16: Computational Modeling of Deep Brain Stimulation
Cameron C. McIntyre

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SECTION III: BIOMEDICAL ENGINEERING CONSIDERATIONS

Introduction
Joseph Pancrazio and P. Hunter Peckham

Chapter 17: Electrodes for the Neural Interface
Dustin J. Tyler and Katharine H. Polasek

Chapter 18: Implantable Neural Stimulators
P. Hunter Peckham and D. Michael Ackermann, Jr.

Chapter 19: Designing a Neural Interface System to Restore Mobility
John P. Donoghue and Leigh Hochberg

Chapter 20: MRI Safety and Neuromodulation Systems
Frank G. Shellock

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SECTION IV: NEUROMODULATION FOR CHRONIC PAIN

Introduction
Elliot S. Krames and Andre Machado

Chapter 21: Physiology and Pathophysiology of Chronic Pain
Joshua M. Rosenow

Chapter 22: The Endogenous Neuromodulation System
Allan I. Basbaum, Joao Braz, Michael H. Ossipov, and Frank Porreca

Chapter 23: Management Strategies for Chronic Pain
Rollin M. Gallagher

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SECTION IV A: Periphery and Spinal Cord Electrical Stimulation for Non-Visceral Pain

Introduction

Chapter 24: Transcutaneous Electrical Nerve Stimulation (TENS): A Review
Kathleen Sluka, Howard S. Smith, and Deirdre M. Walsh

Chapter 25: Mechanisms of Spinal Cord Stimulation in Neuropathic and Ischemic Pain Syndromes
Bengt Linderoth, Robert D. Foreman, and Björn A. Meyerson

Chapter 26: The Cost-Effectiveness of Spinal Cord Stimulation
Richard B. North, Jane Shipley, and Rod S. Taylor

Chapter 27: SCS for Painful Neuropathies
Giancarlo Barolat

Chapter 28: Neurostimulation in the Treatment of Complex Regional Pain Syndrome
Joshua P. Prager

Chapter 29: Peripheral Nerve Stimulation (PNS) for Pain Peripheral Neuralgia and CRPS
Michael Stanton-Hicks

Chapter 30: Occipital Neurostimulation (ONS) for Treatment of Intractable Headache Syndromes
Richard L. Weiner and Kenneth M. Alo`

Chapter 31: Subcutaneous Targeted Stimulation
Teodor Goroszeniuk and Sandesha Kothari

SECTION IV B: Infusional Therapies for Pain

Introduction

Chapter 32: Relevant Anatomy for Spinal Delivery
Timothy R. Deer, Matthew Ranson, and Douglas Stewart

Chapter 33: The Rational Use of Intrathecal Opioid Analgesics
Elliot S. Krames and Mouchir Harb

Chapter 34: Intrathecal Analgesics, Choice of System
Marshall D. Bedder

Chapter 35: Intrathecal Non-Opioid Analgesics for the Control of Pain
Enrique Reig, David Abejón, and Elliot S. Krames

Chapter 36: Compounding Intrathecal Drugs
Richard L. Rauck

Chapter 37: Intracerebroventricular Opioid Administration for Chronic Pain
Katherine E. Groothuis and Robert M. Levy

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SECTION IV C: Brain Stimulation for Pain

Introduction

Chapter 38: Deep Brain Stimulation for Pain
Erlick A. C. Pereira, Sarah L. F. Owen, Alexander L. Green, and Tipu Z. Aziz

Chapter 39: Deep-Brain Stimulation of the Posterior Hypothalamus in Chronic Cluster Headache
A. Franzini, G. Messina, M. Leone, G. Bussone, C. Marras, G. Tringali, and G. Broggi

Chapter 40: Motor Cortex Stimulation for the Treatment of Neuropathic Pain
Jean Paul Nguyen, Jean Pascal Lefaucheur, Sylvie Raoul, Vincent Roualdes, Yann Pereon, and Yves Keravel

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SECTION V: NEUROMODULATION FOR MOVEMENT DISORDERS

Introduction
Donald Weisz and Ron L. Alterman

Chapter 41: Movement Disorders: Anatomy and Physiology Relevant to Deep Brain Stimulation
Brian Harris Kopell, Gregory F. Molnar, and Bradley Hiner

Chapter 42: Deep Brain Stimulation in Parkinson's Disease
Karl Sillay and Philip Starr

Chapter 43: Deep Brain Stimulation for Tremor
Adam P. Burdick, Michael S. Okun, and Kelly D. Foote

Chapter 44: Infusion Therapy for Movement Disorders
Joseph C. Hsieh and Richard D. Penn

Chapter 45: Deep Brain Stimulation for Torsion Dystonia
Ron L. Alterman and Michele Tagliati

Chapter 46: Deep Brain Stimulation in Tourette Syndrome
Veerle Visser-Vandewalle, Yasin Temel, and Linda Ackermans

Chapter 47: Surgical Management of Hemifacial Spasm and Meige Syndrome
Hyun Ho Jung and Jin Woo Chang

Chapter 48: Deep Brain Stimulation (DBS) of the Medial Thalamus for Movement Disorders: The Role of the Centromedianum-Parafascicular Complex
Paolo Mazzone, Alessandro Stefani, and G. Della Marca

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SECTION VI: NEUROSTIMULATION FOR EPILEPSY

Introduction
Ash Sharan and Ali R. Rezai

Chapter 49: Epilepsy: Anatomy, Physiology, Pathophysiology, and Disorders
David King-Stephens

Chapter 50: Vagus Nerve Stimulation for Epilepsy
Arun Paul Amar, Michael L. Levy, Charles Y. Liu, and Michael L. J. Apuzzo

Chapter 51: Deep Brain Stimulation for Epilepsy
Casey H. Halpern, Uzma Samadani, Brian Litt, Jurg L. Jaggi, and Gordon H. Baltuch

Chapter 52: Cerebellar Stimulation for Epilepsy
Steven Falowksi, Ashwini D. Sharan, Amanda Celii, and
Ross Davis

Chapter 53: Closed Loop Stimulation in the Control of Focal Epilepsy
J. Smith, K. Fountas, M. Murro, Y. Park, P. Jenkins, D. Greene, and R. Esteller

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SECTION VII: NEUROMODULATION FOR PSYCHIATRIC DISORDERS

Introduction
Benjamin D. Greenberg

Chapter 54: Electroconvulsive Therapy, Transcranial Magnetic Stimulation, and Vagus Nerve Stimulation for Depression
Linda L. Carpenter, Margaret C. Wyche, Gerhard M. Friehs, and John O'Reardon

Chapter 55: Electrical Brain Stimulation in Treatment-Resistant Obsessive-Compulsive Disorder: Parcellation, and Cyto- and Chemoarchitecture of the Bed Nucleus
of the Stria Terminalis, A Review
Kris van Kuyck, Loes Gabriëls, and Bart Nuttin

Chapter 56: Deep Brain Stimulation for Highly Refractory Depression
Benjamin D. Greenberg

Chapter 57: Surgical Treatment for Refractory Drug Addictions
Bomin Sun, Shikun Zhan, Dianyou Li, and Hemmings Wu

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SECTION VIII: NEUROMODULATION FOR FUNCTIONAL RESTORATION

Introduction
P. Hunter Peckham

Chapter 58: Stimulation for the Return of Hearing
Blake S. Wilson and Michael F. Dorma

Chapter 59: The Development of Visual Prosthetic Devices to Restore Vision to the Blind
Muhammad Memon and Joseph F. Rizzo III

Chapter 60: Stimulation for Return of Function after Stroke
John Chae, Jayme Knutson, and Lynne Sheffler

Chapter 61: Cortical Stimulation for the Treatment of Motor Deficits following Ischemic Stroke
Janna Silverstein and Robert M. Levy

Chapter 62: Stimulation for Return of Upper and Lower Extremity Function
Kevin L. Kilgore, Michael W. Keith, and P. Hunter Peckham

Chapter 63: A Neural Prosthesis for Obstructive Sleep Apnea
Dominique M. Durand

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SECTION IX: NEUROMODULATION OF BODY ORGANS

Introduction
Elliot S. Krames

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SECTION IX A: Cardiovascular

Chapter 64: Neuronal Control of the Heart: Neuromodulation
Jeffrey L. Ardell and Robert D. Foreman

Chapter 65: Disorders of Pacing
Thomas Dresing

Chapter 66: Cardiac Pacemakers—Past, Present, and Future
Guy Amit and Kara J. Quan

Chapter 67: Cardiac Defibrillators
Thomas Dresing

Chapter 68: Spinal Cord Stimulation for Peripheral Vascular Disorders
Svante Horsch and Stefan Schulte

Chapter 69: Spinal Cord Stimulation for Refractory Angina
Mike J. L. DeJongste and Robert D. Foreman

Chapter 70: Neuromodulation and Hypertension
Tara M. Mastracci and Roy K. Greenberg

Chapter 71: Neuromodulation of Cardiac Dysfunction
Sandra Machado, Kwangdeok Lee, and Marc S. Penn

SECTION IX B: Gastrointestinal

Chapter 72: Neural Control of the Colon
Beverley Greenwood-Van Meerveld and Robert D. Foreman

Chapter 73: Spinal Cord Stimulation for Gastrointestinal Painful Disorders
Leonardo Kapural

Chapter 74: Gastric Stimulation for Dysmotility Disorders and Obesity
Cristian Sevcencu

Chapter 75: Intestinal Electrical Stimulation: Methodologies, Effects, Mechanisms, and Applications
Jieyun Yin and Jiande D. Z. Chen

SECTION IX C: Genitourinary

Chapter 76: Neurophysiology of the Genitourinary Organs
William C. de Groat and Firouz Daneshgari

Chapter 77: Sacral Nerve Root Stimulation for Painful Bladder Syndrome/Interstitial Cystitis
Adnan A. Al-Kaisy and K. Riaz Khan

Chapter 78: Neuromodulation for Voiding Dysfunction
Sarah McAchran, Raymond Rackley, and Sandip Vasavada

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SECTION X: EMERGING APPLICATIONS OF NEUROMODULATION

Introduction
Elliot S. Krames and Ali R. Rezai

Chapter 79: Deep Brain Stimulation for Obesity
Michael Y. Oh, David B. Cohen, and Donald M. Whiting

Chapter 80: Deep Brain Stimulation for Blood Pressure Control
Erlick A. C. Pereira, Alexander L. Green, and Tipu Z. Aziz

Chapter 81: Tinnitus
Brian Harris Kopell and David Friedland

Chapter 82: Brain and Cerebrospinal Fluid Infusion Therapies for the Treatment of CNS Disease
Daniel J. Abrams

Chapter 83: Deep Brain Stimulation for Cognitive Neuromodulation
Nicholas D. Schiff

Chapter 84: Novel Neuromodulation Approaches for Alzheimer's Disease and Other Neurodegenerative Conditions
Julie G. Pilitsis and Roy A. E. Bakay

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SECTION XI: NEUROMODULATION DEVICE IMPLANT TECHNIQUES

Introduction
Elliot S. Krames

Chapter 85: Deep Brain Stimulation: Surgical Technique
Andre G. Machado, Alon Y. Mogilner, and Ali R. Rezai

Chapter 86: Spinal Cord Stimulation: Placement of Surgical Leads via Laminotomy—Techniques and Benefits
Krishna Kumar, Goran Lind, Jaleh Winter, Shivani Gupta, Sharon Bishop, and Bengt Linderoth

Chapter 87: Peripheral Nerve Stimulation
Michael Stanton-Hicks

Chapter 88: Subcutaneous Peripheral Nerve Field Stimulation for Intractable Pain
Giancarlo Barolat

Chapter 89: Surgical Placement of Occipital Leads
Richard L. Weiner

Chapter 90: Surgical Technique: Intrathecal Medication Delivery System Implantation
Joshua M. Rosenow

Chapter 91: The Surgical Technique of Vagus Nerve Stimulator Implantation
Jeffrey W. Cozzens

Appendices

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