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Edited By:

Elliot S. Krames, Pacific Pain Treatment Center, San Francisco, CA, USA
P. Hunter Peckham, Case Western Reserve University, Cleveland, OH, USA
Ali R. Rezai, Cleveland Clinic, Cleveland, OH, USA

About the Editors:

Elliot S. KramesElliot S. Krames, Pacific Pain Treatment Center, San Francisco, CA, USA

Dr. Elliot Krames received his MD degree from the University of Maryland Medical School in 1971 and completed his residency in Anesthesiology and fellowship in Obstetrical Anesthesiology at the University of California, San Francisco in 1974.  Dr. Krames served as Director of Obstetrical Anesthesia  at Mt. Zion Hospital of San Francisco from 1975-1983 and during that time he developed a clinical interest in the use of intrathecal morphine, first for parturients in labor and shortly thereafter, for  cancer patients dying  with  intractable pain.  Dr. Krames was the first Director of Cancer Pain Management at Mt. Zion Hospital from 1983-1987 in San Francisco and has been the Medical Director of the Pacific Pain Treatment Center, a private interdisciplinary practice of pain medicine in San Francisco since then.  

Dr. Krames is a world wide recognized leader in the field of pain medicine and neuromodulation, the field of implantable technologies to improve function for mankind.  Dr. Krames is President of the International Neuromodulation Society (INS), Editor in Chief of NEUROMODULATION, technology at the Neural Interface, Journal of the INS and is a co-founder of the National Pain Foundation (NPF).  Dr. Krames presently sits on the Boards of the INS, the North American Neuromodulation Society, and the NPF. He has served on the Boards of the American Academy of Pain Medicine, the American Board of Pain Medicine and the World Institute of Pain.  Dr. Krames is co- author of several books titled, “Pain Medicine, Tools of the Trade” and “Operative Neuromodulation”, has authored or coauthored more than 80 publications and has spoken world wide more than 350 times.  His new book, co-edited by Hunter Peckham, PhD, Chairman of the Department of Bio-Engineering at Case Western University of Cleveland, Ohio and Ali Rezai, MD, PhD, Chairman of the Department of Functional Neurosurgery at the Cleveland Clinic of Cleveland, Ohio, is titled, Neuromodulation is presently in production and will be available in March, 2009.

Dr. Krames is the proud owner of a 300 acre ranch in the foothills of northern California where he grows grapes; he plans to, someday retire to making fine wines for friends, family and colleagues.

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P. Hunter PeckhamP. Hunter Peckham, Case Western Reserve University, Cleveland, OH, USA

P. Hunter Peckham received his undergraduate degree in mechanical engineering from Clarkson College of Technology (now Clarkson University), Potsdam, NY, and his MS and PhD degrees in biomedical engineering from Case Western Reserve University (CWRU), Cleveland, OH. He is currently: Donnell Institute Professor of Biomedical Engineering and Orthopaedics at CWRU; Senior Career Research Scientist, Department of Veterans Affairs; and Director, Orthopaedic Research, MetroHealth Medical Center.  

Dr. Peckham presently serves as the Director of the Functional Electrical Stimulation (FES) Center, a research consortium of the Cleveland Louis Stokes Veterans Affairs Medical Center, Case Western Reserve University and MetroHealth Medical Center.  The Center leads clinical, educational, and technology activities related to restoring function for people with disabilities through the use of electrical activation, and clinical research programs are directed at functional restoration of upper and lower extremities, and bowel and bladder function in spinal cord injury and stroke. 

The major area of Dr. Peckham's research is in rehabilitation engineering and neural prostheses.  Dr. Peckham is internationally known for his research in the utilization of functional electrical stimulation to restore hand/arm control to individuals of high-level spinal cord injury (quadriplegia).  He and his collaborators have developed implantable neural prostheses that utilize electrical stimulation to control neuromuscular activation.  They have implemented procedures to provide control of grasp-release in individuals with tetraplegia.  This function enables individuals who are disabled due to paralysis from central nervous system injury to regain the ability to perform essential activities of daily living.
Dr. Peckham’s present efforts concern the integration of technological rehabilitation and surgical approaches to restore functional capabilities. He is currently working on an advanced neuroprosthesis that employs implantable sensors for internal control and regulation of movement. 

Dr. Peckham’s publications include over 90 journal articles, 27 book chapters and 6 edited books and journals.  Dr. Peckham’s work has been featured in numerous local and national television and radio broadcasts, as well as print and internet feature articles. Research of the FES Center has been included in two museum exhibits; the Great Lakes Science Center in Cleveland and, Science Museum, London, England. 

Major sponsors of Dr. Peckham’s research have included the Department of Veterans Affairs' Rehabilitation Research and Development Service, the National Institutes of Health, the Food and Drug Administration's Office of Orphan Product Development, and the State of Ohio.

He is a fellow of the American Institute of Medical and Biological Engineering and a fellow and honorary member of the American Spinal Injury Association, and was elected to the National Academy of Engineering in 2002.  He is a member of numerous professional organizations.  Dr. Peckham is a member of the NIH National Institute of Bioimaging and Bioengineering National Advisory Council
Dr. Peckham’s most recent awards include:  1999 — "Engineer of the Year" by Design News Magazine; 2001 — Magnuson Award by the Department of Veterans Affairs; 2004 — Maurice Saltzman Award to the Cleveland VA FES Center; 2006 — Golden Knight Award, Clarkson University; 2006 — World Technology Network, Award in Health and Medicine

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Ali R. RezaiAli R. Rezai MD
Julius F. Stone Endowed Chair
Professor of Neurosurgery
Director, OSU Center for Neuromodulation
Director, Functional Neurosurgery
Director, Neurosurgical Innovations
Vice Chair, Neurosurgery Clinical Research
The Ohio State University
Department of Neurological Surgery  

Dr. Rezai earned his medical degree with honors from the University of Southern California and underwent neurosurgical training at New York University. He completed his subspecialty training in functional neurosurgery at the University of Toronto and the Karolinska Institute in Stockholm, Sweden. He then joined the neurosurgical faculty at New York University Medical Center, becoming the director of the Center for Functional and Restorative Neurosurgery until January 2000, when he joined the faculty at the Cleveland Clinic Foundation.

A board certified neurosurgeon, Dr. Rezai's clinical areas of expertise are the neurosurgical management of patients with severe movement disorders such as Parkinson's disease and dystonia, psychiatric conditions such as depression and obsessive compulsive disorder, traumatic brain injury and chronic pain. Dr. Rezai was named one of the best doctors in America in Castle and Connolly's Guide to America's Top Doctors for 2001-2008.

Dr. Rezai has published over 100 articles and more than 20 book chapters. He serves on the editorial board of Neurosurgery Journal, among others. He has edited a book on neurosurgery for the treatment of psychiatric disorders and is also an editor for the upcoming book, Neuromodulation. In addition, Dr. Rezai has been the Principal (PI) and Co-investigator on several NIH grants, and was the PI of the state of Ohio Brain Neuromodulation Center. He has delivered over 300 lectures nationally and internationally and chaired numerous symposia and meetings. In 2007, Dr. Rezai presented his work to the President of the United States as well as to members of the US Senate and House of Representatives on Capitol Hill.

Dr. Rezai currently holds the Jane and Lee Seidman Chair in Functional Neurosurgery at the Cleveland Clinic. He is the recipient of NorTech's annual Innovation Award, the Bottrell Neurosurgical Award, The Congress of Neurological Surgeons Clinical Fellowship award, and the American Association of Neurological Surgeons Investigator Award. Dr. Rezai is also a member of the Executive Board of the Congress of Neurological Surgeons (CNS), North American Neuromodulation Society (NANS), and the American Society of Stereotactic and Functional Neurosurgery (ASSFN). He is currently the Vice President of NANS and ASSFN organizations.  

Dr. Rezai's research focus involves neuroscience and imaging to delineate abnormal brain circuitry underlying disease processes, as well as developing novel therapeutic strategies for treatment of neurological and psychiatric disorders. He has been involved in pioneering work involving the use of brain pacemakers for treating Parkinson's disease, depression, obsessive compulsive disorder and traumatic brain injury, and holds seven US patents. 

Dr. Rezai received the Achievement of the Year Award for Health and Medicine from Northern Ohio Live magazine. His work has been featured in publications such as the Wall Street Journal, New York Times, US News and World Report, USA Today, MIT's Technology Review magazine, Newsweek, Time, The Washington Post, The Los Angeles Times and The Cleveland Plain Dealer. He was featured in Crains' Who's Who in Biotech and listed as one of the "40 Under 40," and has appeared on numerous local and national radio and television broadcasts including CBS' 60 Minutes, Prime Time, The Charlie Rose Show, The Diane Rehm Show, CNN, NPR, PBS, the BBC, MSNBC, ABC, NBC and CBS Nightly News and The Discovery Channel.

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