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Introduction
The
Bone Organ System: Form and Function
Elise F. Morgan, George L. Barnes, and Thomas A. Einhorn
The Nature
of Osteoporosis
Robert Marcus and Mary Bouxsein
The Economics of Osteoporosis
Anna N.A. Tosteson and David J. Vanness
Reflections on Osteoporosis
B. E. Christopher Nordin
Skeletal Heterogeneity and the Purposes of Bone Remodeling:
Implications for the Understanding of Osteoporosis
Michael Parfitt
Basic Science/Bone Biology
Osteoblast Biology
Jane B. Lian and Gary S. Stein
Osteoclast Biology
Harry C. Blair, Scott Simonet, David L. Lacey, and Mone Zaidi
Osteocytes
Lynda F. Bonewald
The Regulatory Role of Matrix Proteins in Mineralization
of Bone
Wei Zhu, Pamela Gehron Robey and Adele L. Boskey
Development of the Skeleton
Sylvain Provot, Ernestina Schipani, Joy Wu and Henry Kronenberg
Mouse Genetics as a Tool to Study Bone Development and
Physiology
Clifford J. Rosen and Wesley G. Beamer
Parathyroid Hormone and Parathyroid Hormone-Related Protein
Robert A. Nissenson
Vitamin D: Biology, Action, and Clinical Implications
David Feldman, Peter J. Malloy, Aruna V. Krishnan and Eva Balint
Regulation of Bone Cell Function by Estrogens
Barry S. Komm, Boris Cheskis and Peter V.N. Bodine
Androgens and Skeletal Biology: Basic Mechanisms
Kristine M. Wiren
Phosphatonins
Peter J. Tebben, Theresa J. Berndt, and Rajiv Kumar
Wnt Signaling in Bone
Mark L. Johnson nd Robert R. Recker
Cytokines and Bone Remodeling
Gregory R. Mundy, Babatunde Oyajobi, Gloria Gutierrez, Julie Sterling,
Susan Padalecki, Florent Elefteriou, Ming Zhao
Skeletal Growth Factors
Ernesto Canalis
Intercellular Communication During Bone Remodeling
T. John Martin and Gideon A. Rodan
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Structural and Biomechanics
Skeletal Development: Mechanical Consequences
of Growth, Aging and Disease
Marjolein C.H. van der Meulen and Dennis R. Carter and Gary S.
Beaupré
Inhibition of Osteoporosis by Biophysical Intervention
Clinton T. Rubin, Stefan Judex, Janet Rubin and Yi-Xian Qin
Biomechanics of Age-Related Fractures
Mary L. Bouxsein
Bone Quality
J. Christopher Fritton and Mitchell B. Schaffler
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Epidemiology & Risk
Factors
Epidemiologic Methods in Studies of Osteoporosis
MaryFran Sowers and Carrie A. Karvonen-Gutierrez
Race, Ethnicity and Osteoporosis
Dorothy A. Nelson, John M. Pettifor and Shane A. Norris
The Study of Osteoporotic Fractures (SOF): Major Findings and Contributions
Jane A. Cauley, Kristine E. Ensrud, Teresa A. Hillier, Marc Hochberg,
Katie L. Stone, Steven R. Cummings
Bone Mineral Acquisition in Utero and During Infancy and Childhood
Jon Burnham and Mary B. Leonard
Bone Acquisition in Adolescence
Moira A. Petit, Heather M. Macdonald, Heather A. McKay and Tom
Lloyd
Genetic Determinants of Osteoporosis
André G. Uitterlinden, Fernando Rivadeneira, Hans P.T.M.
van Leeuwen, Joyce B.J. van Meurs, Huibert A.P. Pols
Nutrition and Risk for Osteoporosis
Robert P. Heaney
Physical Activity in Prevention of Osteoporosis and Associated
Fractures
Kirsti Uusi-Rasi, Pekka Kannus, Harri Sievänen
Premenopausal Reproductive and Hormonal Characteristics and the
Risk for Osteoporosis
MaryFran Sowers
Non-Skeletal Risk Factors for Osteoporosis and Fractures
Jeri W. Nieves
Falls as Risk Factors for Fracture
Sarah D. Berry and Douglas P. Kiel
Assessment of Fracture Risk
Nguyen Dinh Nguyen and Tuan V. Nguyen
Outcomes of Osteoporotic Fractures
Gail A. Greendale and Elizabeth Barrett-Connor
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Pathophysiology
Local and Systemic Factors in the Pathogenesis
of Osteoporosis
Lawrence G. Raisz
Animal Models for Osteoporosis
Urszula T. Iwaniec and Russell T. Turner
Estrogen, Bone Homeostasis and Osteoporosis
B. Lawrence Riggs, Sundeep Khosla, and L. Joseph Melton III
Postmenopausal Osteoporosis: How the Hormonal Changes of Menopause
Cause Bone Loss
Roberto Pacifici
Osteoporosis in Men: Epidemiology, Pathophysiology, and Clinical
Characterization
Eric Orwoll and Robert Klein
Osteoporosis in Childhood and Adolescence
Leanne Ward and Laura K. Bachrach
Glucocorticoid-Induced Osteoporosis
Robert A. Adler, Jeffrey Curtis, Robert S. Weinstein
and Kenneth G. Saag
Adult Scoliosis, Degenerative Disease, and BMD: a Sub-Segmental
Analytic Approach
Alan L. Burshell and Eric A. Nauman
Mechanisms of Immobilization-induced Bone Loss
Bernard Halloran
Leptin-Dependent Regulation of Bone Mass
Gerard Karsenty
Thyroid Hormone and the Skeleton
Daniel Baran
Osteoporosis in Gastrointestinal, Pancreatic, and Hepatic Disease
Daniel Bikle
The Skeletal Actions of Parathyroid Hormone in Primary Hyperparathyroidism
and in Osteoporosis
John P. Bilezikian, Lorraine A. Fitzpatrick, and Shonni J. Silverberg
Osteogenesis Imperfecta and Other Defects of Bone Development
as Occasional Causes of Adult Osteoporosis
Jay R. Shapiro
Osteoporosis Associated with Illnesses and Medications
Hyesoo Lowe and Elizabeth Shane
Transplantation Osteoporosis
Sol Epstein
Osteoporosis Associated with Cancer Therapy
Ailleen Heras-Herzig, Wende M. Kozlow, Sue A. Brown and Theresa
A. Guise
Osteoporosis Associated with Pregnancy
Rachel B. Wagman and Robert Marcus
Osteoporosis Associated with Rheumatologic Disease
Steven Goldring
Oral Bone Loss and Systemic Osteopenia: Potential Treatment and
Risks
Marjorie K. Jeffcoat
Localized Osteoporosis
D.J. Schurman, W.J. Maloney, and R.L. Smith
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Evaluation and Management
Evaluation of the Patient with Osteoporosis
or at Risk for Osteoporosis
Rekha Nugaram, Aysegul Atmaca, and Michael Kleerekoper
Who Should be Screened: Who Should be Treated?
Michael R. McClung
Radiology of Osteoporosis
Michael Jergas and Harry K. Genant
Clinical Use of Bone Densitometry
Kenneth G. Faulkner and Paul D. Miller
Biochemical Markers of Bone Turnover in Osteoporosis
Pawel Szulc and Pierre D. Delmas
The Conundrum of Compliance and Persistence with Oral Bisphosphonates
for Postmenopausal Osteoporosis
Deborah T. Gold and Samantha Solimeo
An Orthopedic Perspective of Osteoporosis
Charles Reitman, Kenneth Mathis and Michael H. Heggeness
Lessons from Bone Histomorphometry on the Mechanism of Action of
Osteoporosis Drugs
Hua Zhou and David W. Dempster
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Pharmacology and Therapeutics
Design Considerations for Clinical
Investigations of Osteoporosis
Robert P. Heaney
Regulatory Considerations for the Design and Conduct of Osteoporosis
Registration Trials
Bruce H. Mitlak
Evidence-Based Osteoporosis Care
Kurt A. Kennel, Brian A. Swiglo, and Victor M. Montori
The Role of Calcium in the Treatment of Osteoporosis
René Rizzoli
Vitamin D and its Metabolites and Analogs in the Management of
Osteoporosis
Roger Bouillon and Ian R. Reid
Estrogen Therapy: Prevention and Treatment of Osteoporosis
Joan A. McGowan and Marcia L. Stefanick
Estrogen Analogues: Selective Estrogen Receptor Modulators (SERMs)
and Phytoestrogens
Richard Prince, Douglas B. Muchmore and Ethel S. Siris
Bisphosphonates: Pharmacology and Use in the Treatment of Osteoporosis
Paul D. Miller
Calcitonin in Osteoporosis
Roberto Civitelli
Strontium Therapy for Osteoporosis
Ego Seeman
Androgens
Peter J. Snyder
Treatment with PTH Peptides
Felicia Cosman and Robert Lindsay
Growth Hormone and Insulin-like Growth Factors: Potential Applications
and Limitations in the Management of Osteoporosis
Clifford J. Rosen and Tim Niu
New Approaches to Osteoporosis Therapeutics
Rivka Dresner-Pollak, S. Aubrey Stoch and Michael Rosenblatt
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