Chromatin Regulation and Dynamics
Edited by: Anita Göndör, Assistant Professor, Department of Microbiology, Tumor, and Cell Biology (MTC), Karolinska Institutet, Solna, Sweden
Description
Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, and then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The book also covers the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases.
Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, as part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation.
Key Features
- Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspective
- Promotes crosstalk between basic sciences and their applications in medicine
- Provides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principles
- Integrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes
Readership
Geneticists, clinical researchers, life science researchers, MD/clinicians who want to learn about epigenetics and chromatin, cell biologists, pharmaceutical scientists, molecular biologists and biochemists
Table of Contents
- A brief introduction to chromatin regulation and dynamics
Ilias Tzelepis, Mirco Martino and Anita Göndör - The dynamics and function of DNA methylation during development
Andreas Lennartsson - Histone modifications and variants in pluripotency, neural cell fate specification, and in differentiated cell states in the central nervous system
Andrew J. Bannister, Ana Mendanha Falcão, Gonçalo Castelo-Branco - ATP-dependent chromatin remodeling: from development to disease
Marco Lezzerini and Christian G. Riedel - Regulation of cellular identity by Polycomb and Trithorax proteins
M. Wassef and R. Margueron - Chromatin Dynamics During the Cell Cycle
Detlef Doenecke - Epigenetic regulation of replication and replication timing
Caroline Brossas, Anne-Laure Valton, Bénédicte Duriez and Marie-Noëlle Prioleau - Interplay between Chromatin and Splicing
Ana Fiszbein, Micaela A. Godoy Herz, Luciana I. Gomez Acuña and Alberto R. Kornblihtt - Crosstalk between long non-coding RNAs and the epigenome in development
Maria Berdasco and Manel Esteller - Chromatin remodelling and transcription of ribosomal genes
Ann-Kristin Östlund Farrants - Chromatin Dynamics and DNA Repair
Poonam Agarwal and Kyle M. Miller - Regulation of Centromeric Chromatin
Debora Bade and Sylvia Erhardt - Telomere maintenance in the dynamic nuclear architecture
Emanuela Micheli, Alessandra Galati, Alessandro Cicconi and Stefano Cacchione - Epigenetic Regulation of X-Chromosome Inactivation
Mary E. Donohoe - Chromatin Dynamics and Cellular Metabolism
Samantha J. Linder and Raul Mostoslavsky - Circadian Plasticity of Chromatin States
William J. Belden - 3D Nuclear Architecture and Epigenetic Memories: Regulators of Phenotypic Plasticity in Development, Aging and Cancer
Barbara A. Scholz, Lluís Millán-Ariño and Anita Göndör
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https://www.elsevier.com/books/chromatin-regulation-and-dynamics/gondor/978-0-12-803395-1