Elsevier · Tollefsbol, T: Translational Epigenetics Series · Neuropsychiatric Disorders and Epigenetics

Neuropsychiatric Disorders and Epigenetics

Edited by: Dag Yasui, University of California, Davis, California, USAJacob Peedicayil, Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, Tamil Nadu, IndiaDennis R. Grayson, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, Illinois, USA

Description

Neuropsychiatric Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addition to obesity contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant o disease.

Recent discoveries in epigenetic research enabled by epic advances in genomic technologies have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders Neuropsychiatric disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with enormous costs to society. Thus, this volume will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development.

Key Features

  • Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction
  • Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists
  • Extensive use of diagrams, illustrations, tables, and graphical abstracts for each section providing rapid assessment

Readership

Graduate level doctoral students, medical students, clinicians, academic scientists, policy makers and applied scientists are the target audience for this volume. The work should appeal to those involved in genetic, biochemical, neuroscience, molecular biologic, pharmaceutical and psychiatric research.

Table of Contents

    Preface
    Dag H. Yasui, Jacob Peedicayil and Dennis R. Grayson

    Section I. Neuropsychiatric Disorders and Epigenetics: General Aspects

  1. Introduction to Neuropsychiatric Disorders and Epigenetics
    Dag H. Yasui, Jacob Peedicayil and Dennis R. Grayson
  2. Environmental Factors and Epigenetics of Neuropsychiatric Disorders
    Anke Hoffmann and Dietmar Spengler
  3. Epigenetic Biomarkers in Neuropsychiatric Disorders
    Chin-Chuen Lin, Tiao-Lai Huang

    4. Section II: Epigenetics of Neuropsychiatric Disorders

  4. Epigenetics and Cognitive Disorders -Translational Aspects
    Fabio Coppedè
  5. Epigenetics in Pervasive Developmental Disorders - Translational Aspects
    Takeo Kubota
  6. Epigenetic causes of intellectual disability – the fragile X syndrome paradigm
    Elisabetta Tabolacci, Giovanni Neri
  7. Epigenetics of Attention-Deficit Hyperactivity Disorder
    Nader Perroud, Sébastien Weibel, Jean-Michel Aubry, Alexandre Dayer
  8. The epigenetics of brain aging and psychiatric disorders
    Huan Gong, Xiangru Xu
  9. Epigenetic therapy may alleviate cognitive deficits in Down syndrome by downregulating overexpressed chromosome 21 gene products
    Alain D. Dekker, Peter P. De Deyn and Marianne G. Rots
  10. Epigenetics and Multiple Sclerosis
    Lara Kular, Gonçalo Castelo-Branco and Maja Jagodic
  11. Epigenetics and Migraine
    Siew Hua Gan and Munvar Miya Shaik
  12. The role of epigenetics in the pathophysiology of epilepsy
    Sung Min Nam and Kyung-Ok Cho
  13. Epigenetic Dysregulation in Brain Tumors and Neurodevelopment
    Marco M. Hefti and Nadejda Tsankova
  14. Epigenetics and Cerebrovascular Diseases
    Carolina Soriano-Tárraga, Jordi Jiménez-Conde and Jaume Roquer
  15. Epigenetics and Eating Disorders
    Helge Frieling, Vanessa Buchholz
  16. Epigenetics in Obesity
    Brian M. Shewchuk
  17. Epigenetics and Drug Addiction-Translational Aspects
    Jian Feng
  18. Epigenetics and Alcohol Use Disorders
    Sneha Sagarkar and Amul Sakharkar

    19. Section III: Summary and Outlook

  19. Summary and Outlook
    Dag H. Yasui, Jacob Peedicayil and Dennis R. Grayson

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