Elsevier · Tollefsbol, T: Translational Epigenetics Series · Medical Epigenetics

Medical Epigenetics

Edited by: Trygve O. Tollefsbol, Director of the Cell Senescence Culture Facility, University of Alabama at Birmingham, AL, USA

Description

Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management.  The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases.  The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics.  The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics.  Research in the area of translational epigenetics is a cornerstone of this volume.

Key Features

  • Critical reviews dedicated to the burgeoning role of epigenetics in medical practice
  • Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine
  • Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine

Readership

Geneticists, clinical researchers, and clinicians studying the underlying basis of human disease and novel means to treat human diseases that are caused by reversible epigenetic processes

Table of Contents

    Section I:  Overview

  1. An Overview of Medical Epigenetics
    Trygve O. Tollefsbol

    2. Section II:  Basic Principles of Epigenetics

  2. DNA Methylation:  Basic Principles
    Cynthia A. Moylan and Susan K. Murphy
  3. Histone-deacetylases as a therapeutic target in neurodegenerative diseases
    Farahnaz Sananbenesi and Andre Fischer
  4. Basic principles of noncoding RNAs in epigenetics
    Ilaria Panzeri, Grazisa Rossetti and Massimiliano Pagani

    5. Section III:  General Medical Aspects of Epigenetics

  5. Epidemiological Epigenetics in Medicine
    Alexander  Vaiserman
  6. Lifestyle and Preventive Medical Epigenetics
    Marcus V. Gomes
  7. Environmental Medical Epigenetics: A Review of Epigenetically-induced Medical Risks Generated from Exposures in Our Air, Food, and Personal Products
    Rachel L. Miller
  8. Behavioral Medical Epigenetics
    Olivia H. Cox and Richard S. Lee
  9. Medical Epigenetics in Twins
    Joel C. Eissenberg
  10. Epigenetic Biomarkers of Disease
    Philip D. Voyias, Abhilasha Patel and Ramesh P. Arasaradnam
  11. Prognostic Epigenetics
    Anup Sharma, Eihab Abdelfatah, Maryam Al Eissa and Nita Ahuja

    12. Section IV:  Epigenetics of System Disorders

  12. Immune System Disorders and Epigenetics
    Stuti Mehta and Kate L. Jeffrey
  13. Pulmonary Diseases and Epigenetics
    Hong Peng, Dandan Zong, Zijing Zhou and Ping Chen
  14. Cardiovascular Disorders and Epigenetics
    Charbel Abi Khalil
  15. Epigenomics of Intestinal Disease
    Daniel Rory Kelly and Theresa Alenghat
  16. Epigenetics of Skin Disorders
    Shuaihantian Luo and Qianjin Lu
  17. Epigenetics in Bone and Joint Disorders
    N. Altorok, S. Nada, V. Nagaraja and Bashar Kahaleh
  18. Epigenetics of Muscle Disorders
    Viviana Moresi, Nicoletta Marroncelli, Eva Pigna and Sergio Adamo
  19. Epigenetics of Psychiatric Disorders
    Marija Kundakovic
  20. Epigenetic Alterations in Endocrine-dependent Cancers:  Implications of Endocrine Dysfunctions 
    Genevieve Deblois and Mathieu Lupien
  21. Reproductive Disease Epigenetics
     Rafael Oliva
  22. Epigenetics in Ocular Medicine
    Verity F. Oliver, Katherine A. van Bysterveldt and Shannath L. Merbs

    23. Section V:  Multi-system Medical Epigenetics

  23. Pediatric Diseases and Epigenetics
    Judith G. Hall
  24. Epigenetics of Infectious Diseases
    Kate L. Seib and Michael P. Jennings
  25. Clinical Utility of Solid Tumor Epigenetics
    Søren Kristiansen and György Sölétormos
  26. Epigenetic Control in Human Normal Follicular Thyroid Cells and in Thyroid Carcinoma
    Zeus Andrea Antonello and Carmelo Nucera
  27. Epigenetics in Acute Myeloid Leukemia
    Cristina Giorgio, Carmela Dell’Aversana and Lucia Altucci
  28. Epigenetic Regulation in Cancer Metastasis
    Huan Wang, Yukun Zhang, Adam Kriska and Hong Chen
  29. Epigenetics in Exercise Science and Sports Medicine
    Philipp Zimmer, Alexander Schenk and Wilhelm Bloch
  30. Epigenetic Mechanisms and Inheritance of Acquired Susceptibility to Disease
    Rajesh C. Miranda, Nihal A. Salem, Annette S. Fincher, Amanda H. Mahnke and Sasha G. Burrowes

    31. Section VI.  Pharmacology of Epigenetics

  31. Toxicology and Epigenetics
    Jian Tajbakhsh and Jatinder Singh
  32. Pharmacoepigenomics
    Ramón Cacabelos and Clara Torrellas

    33. Section VII:  Therapeutic Epigenetics

  33. Therapeutics and DNA Methylation Inhibitors
    Sheena Bhalla and Shyamala C. Navada
  34. Histone Deacetylase Inhibitors in Medical Therapeutics
    Pusoon Chun
  35. NAD+-dependent Deacetylases and Medical Therapy
    Ashok Kumar, Louisa Ben-Aderet, Jinan Elayan and Mona Dvir-Ginzberg
  36. Experimental Approaches Towards Histone Acetyltransferase Inhibitors as Therapeutics
    H. Wapenaar and Frank J. Dekker
  37. Histone Methylation Modifiers in Medical Therapeutics
    Patrick Trojer
  38. Therapeutics of Epigenetic-based RNA molecules
    Costas Koufaris and Vicky Nicolaidou
  39. Natural Epigenetic-modifying Molecules in Medical Therapy
    Avinash Kumar, Nasir A. Butt and Anait S. Levenson
  40. Outcome of Combining Epigenetic Drugs with Other Treatments in the Clinic
    Paromita Raha
  41. Epigenetics of Pain Management
    Beverley Greenwood-Van Meerveld, Dawn Prusator, Casey Ligon, Anthony C. Johnson and Rachel D. Moloney
  42. Personalized Epigenetics
    Michael Bitzer and Nisar P. Malek
  43. Epigenetics and Regenerative Medicine: Neural and Skeletal Muscle Perspectives
    Constantin Heil and Daniela Palacios
  44. Stem Cell Epigenetics in Medical Therapy
    Baoli Cheng, Liqi Shu and Peng Jin

    45. Section VIII:  Medical Epigenetics:  Future Prospects

  45. Prospective Advances in Medical Epigenetics
    Junjie Xiao and Guoping Li

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