Epigenomics in Health and Disease
Edited by Mario Fraga, Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Cancer Epigenetics Laboratory, Institute of Oncology of Asturias (IUOPA), Universidad de Oviedo, Oviedo, Spain and Agustin F. Fernandez, Cancer Epigenetics Laboratory, Institute of Oncology of Asturias (IUOPA), HUCA, Universidad de Oviedo, Oviedo, Spain
Description
Epigenomics in Health and Disease discusses the next generation sequencing technologies shaping our current knowledge with regards to the role of epigenetics in normal development, aging, and disease.
It includes the consequences for diagnostics, prognostics, and disease-based therapies made possible by the study of the complete set of epigenetic modifications to the genetic material of human cells.
With coverage pertinent to both basic biology and translational research, the book will be of particular interest for medical and bioscience researchers and students seeking current translational knowledge in epigenesis and epigenomics.
Coverage includes the latest findings on epigenome-wide research in disease-based profiling, epidemiological implications, epigenome-wide epigenetic studies, the cancer epigenome, and other pervasive disease categories.
Key Features
- Presents critical reviews that provide the means for reviewing and analyzing the epigenome as a whole, also discussing its translational potential
- Combines basic epigenomic knowledge with methodological and biostatistical topics related to technology and data analysis
- Includes coverage of relatively new topics, including DNA methylation dynamics during development and differentiation, genome-wide histone post-translational modifications during development and differentiation, and genome-wide DNA methylation changes during aging
Readership
Graduate students, health care professionals, university researchers, pharmaceutical companies interested in drug development and biotechnology companies. This book could also serve as a core textbook for advanced university or professional school courses with a focus on genetic and/or human diseases.
Table of Contents
- An Introduction to Epigenetics
- The Study of the Epigenome: Technical Approaches
- Epigenomics vs genomics: effects of the tissue specificity and stability over time
- DNA Methylation Microarrays
- Ultra Deep Sequencing of Bisulfite Modified DNA
- Bioinformatic Tools in Epigenomic Studies
- Genome-Wide Non-Coding RNA Regulation of Health and Disease
- Genome-Wide DNA Methylation Changes During Aging
- The Dynamics of Histone Modification During Aging
- Epigenomic Studies in Epidemiology
- The DNA Methylomes of Cancer
- Genome-Wide Epigenetic Studies in Neurological Disorders
- Epigenomic Profiling in Diseases of the Immune System
- Genome-Wide DNA and histone Modification Studies in Metabolic Disease
- Clinical Applications of Epigenomics
Available now at Store.Elsevier.com